• Home
  • Browse Issues
    • In Press
    • Current Issue
    • Special Issue
    • Past Issues
  • About
    • Editorial Board
    • Bibliographic Listings
    • Peer Review Process
    • Open Access Policy
    • Plagiarism Policy
    • Copyright Policy
    • Retraction Policy
    • Editorial Policy
    • Disclaimer
  • Author Guidelines
  • Submit Article
  • Contact

Subscribe to Updates

Get the latest creative news from FooBar about art, design and business.

Facebook Twitter Instagram
International Journal of Pharmaceutical Investigation
Facebook Twitter Instagram
Submit Article Author Guidelines
  • Home
  • Browse Issues
    1. In Press
    2. Current Issue
    3. Special Issue
    4. Past Issues
    5. View All

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023
  • About
    • Editorial Board
    • Bibliographic Listings
    • Peer Review Process
    • Open Access Policy
    • Plagiarism Policy
    • Copyright Policy
    • Retraction Policy
    • Editorial Policy
    • Disclaimer
  • Author Guidelines
  • Submit Article
  • Contact
International Journal of Pharmaceutical Investigation
Home»JPHI»Vol 13 Issue 3»In vitro Anti-cancer Activity of Nandhi mezhugu (NM) in Ovarian Cancer Cell Line (PA-1) Using MTT Assay
Vol 13 Issue 3

In vitro Anti-cancer Activity of Nandhi mezhugu (NM) in Ovarian Cancer Cell Line (PA-1) Using MTT Assay

July 5, 2023Updated:July 7, 20232 Mins Read
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

International Journal of Pharmaceutical Investigation, 2023, 13, 3, 646-650.
DOI:10.5530/ijpi.13.3.080
Published: July 2023
Type: Original Article

Authors: 

Glara Anest Francis
National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamilnadu, INDIA.

Sureka Arumugam
National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamilnadu, INDIA.

Sabari Girija Navaneetha Krishnan
National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamilnadu, INDIA.

Ramamurthy Murugan
Department of Noinadal, National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamilnadu, INDIA.

Christian Gnanaraj Johnson
Department of Noinadal, National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamilnadu, INDIA.

Moses Erin Johnson Christian
Caucasus International University, Tbilisi, GEORGIA.

Meenakumari Ramasamy
National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamilnadu, INDIA.

ABSTRACT

Introduction: Ovarian cancer is the fifth most common cause of cancer which causes more deaths than any other cancer of the female reproductive system because there is no effective screening and most women are diagnosed at advanced stages. The probability of survival at 5 years is less than 30%, and the limitation is that it will not respond to chemotherapy protocol and surgery as well. Nandhi mezhugu is a Siddha herbo-mineral drug widely used to treat cancer. Hence, the present study was intended to evaluate the anti-cancer activity of Nandhi mezhugu on (PA-1) cell line through MTT assay. Materials and Methods: Stock solutions were prepared from the formulation at various concentrations with serial dilution. Compared with the control and Methotrexate, the extracts were tested using MTT assay at different concentrations. Results: This study substantiated that the percentage of cell viability of cell line viability decrease with increase in concentration of the test drug NM. Least viability of cell was observed at the concentration of 200μg/mL was 73.02 ± 4.584%, followed by this at 100 μg and 50 μg shows 82.36 ± 3.084%, 87.81 ± 2.657, similarly 10 μg/mL shows 95.89 ± 1.054% cell viability in MTT assay. Conclusion: Thus, the current study brings forth scientific evidence for the efficacy of Nandhi mezhugu against the ovarian cancer (PA1) cell line.

Keywords: Anti-cancer activity, Ovarian cancer, Nandhi mezhugu, PA1 cell line, Siddha.

Original Article
Previous ArticleInvestigation of Phytochemical Profile of Ethanolic Extract of Elaeocarpus ganitrus and Desmostachya bipinnata
Next Article Monitoring Adverse Medication Reactions: Aiding Pharmacovigilance at a Hospital Providing Secondary Care

Related Posts

Impact of Mobile Radiations on Gliclazide Tablet Formulation

July 21, 2023

Formulation and in vitro Evaluation of pH Dependent Colon Targeted Controlled Release Tablet of Mesalamine Containing Cyamopsis tetragonoloba Gum and Sodium Alginate

July 21, 2023

Formulation, Development and Characterization of Liposome-based Gel of Eberconazole Nitrate for Topical Delivery

July 21, 2023
Download PDF
Cite this Article
Citation Output

Read in Readcube
  • Download PDF
  • ReadCube
Citations & Metrics
Article Metrics
  • Dimensions Metrics
  • Page Views
  • Related
Total Views 0
Last Month Views 0
Click for PLUM.MX Metrics Search this article in Google Scholar Related Articles in Google Scholar Search related in PUBMED


About
About

publishing peer-reviewed scholarly reviews, themed issues and research articles within the entire scope of the Pharmaceutical field. The journal particularly aims to foster the dissemination of scientific information by publishing manuscripts related to Pharmacy and Related Fields.

We're accepting new submissions right now.

Facebook Twitter RSS
Editor Picks

Overview on Evolving Variants of Novel Coronavirus and Control Measures in India

July 5, 2023

An Overview of the Various Appropriate Types of Cell Lines for the Production of Monoclonal Antibodies

July 5, 2023

Ashwagandha: A Flagship Herb of Ayurveda from Past to Present Nano Era

July 5, 2023

Dental Pulp Stem Cells: Biology and Promise for Regenerative Medicine

July 5, 2023
STAY CONNECTED

Contact Editor-In-Chief
Editor, International Journal of Pharm Investigation
#9, Vinnse Tower, Wheeler Road Extn.
St. Thomas Town, 560084, Bangalore, INDIA
Email: editor@jpionline.org

© 2023 Phcog.Net | Published by : EManuscript.
  • Home
  • Submit Article
  • Disclaimer
  • Contact

Type above and press Enter to search. Press Esc to cancel.