International Journal of Pharmaceutical Investigation, 2021, 11, 4, 384-388.
DOI: 10.5530/ijpi.2021.4.69
Published: December 2021
Type: Original Article
Authors:
Ferdos Kord Mostafapour
Department of Environmental Health Engineering, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, IRAN.
Maryam Bazi
Student Research Committee, Zahedan University of Medical Sciences, Zahedan, IRAN.
Shaziya Haseeb Siddiqui
Department of Chemistry, Sam Higginbottom University of Agriculture Technology and Sciences (SHUATS), Allahabad, Uttar Pradesh, INDIA.
Hossein Bagheri
Department of Medical Language, Zahedan University of Medical Sciences, Zahedan, IRAN.
Davoud Balarak
Department of Environmental Health Engineering, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, IRAN.
ABSTRACT
Background: Antibiotics have lasting effects on the environment. Among the properties of these substances are non-biodegradable, carcinogenic, high toxicity, and an increase in antibiotic-resistant bacteria. Therefore, they should be removed from aqueous solutions and the point of this think was to adsorb amoxicillin (AMO) by magnetic graphene oxide nanocomposite (MGO). Methods: The adsorption behavior of AMO was studied in a series of batch experiments as a function of pH (3-11), contact time (0-120 min), and AMO concentration (10-100 mg/L) different MGO dosages (0.1-1 g/L). The structures of MGO were confirmed by scanning electron microscope (SEM), and the X-ray diffraction (XRD). Results: The results revealed in optimized conditions (pH=3, contact time=75 min, AMO concentration= 10mg/L and adsorbent dose=0.75 g/L) maximum adsorption capacity and removal efficiency of AMO were 98.41 mg/g, respectively. The thermodynamical parameters showed that the sorption method was endothermal and spontaneous. Conclusion: MGO nanoparticles have extended capabilities such as easy and rapid separation from solution and high potential in removing AMO, so, it can be introduced as an appropriate adsorbent for removal of this antibiotics from water and wastewater.
Keywords: Amoxicillin, Magnetic graphene oxide, Thermodynamics, Adsorption, Nanocomposite .