International Journal of Pharmaceutical Investigation, 2023, 13, 3, 516-525.
DOI:10.5530/ijpi.13.3.064
Published: July 2023
Type: Original Article
Authors:
Prasenjit Mondal
Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata, INDIA.
Aditya Sarkar
Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata, INDIA.
Sourav Dutta
Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata, INDIA.
Piyali Khamkat
Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata, INDIA.
Vivek Barik
Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata, INDIA.
Sumanta Mondal
Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, INDIA.
ABSTRACT
Objectives: In this work, the photo components were investigated utilising GC-MS analysis and in vitro antioxidant activity, and the anthelmintic potential of methanolic extract of aerial parts of the Lagenaria siceraria (MEALS). By using the soxhlation method. Materials and Methods: MEALS were made from aerial components, and phytochemical analysis was carried out for a qualitative evaluation. The in vitro antioxidant activity was measured using the ABTS technique, and the current extract was utilised to analyse phytocomponents by GC-MS and study anthelmintic activity on Pheretima posthuma. The extract of Lagenaria siceraria included 59 components, according to the GC-MS study’s phytochemical analysis. Results: Results from anthelmintic research reveal that MEALS had paralysis times between 4.76 and 2.17 min and death times between 6.18 and 2.34 min when compared to the medicine Albendazole, which is the gold standard (paralysis time 4.76 min to 2.17 min and death time 5.87 min to 1.96 min on Peritima posthuma in increasing order of concentration). The percentage of scavenging ranged from 33.31% to 82.33% (IC50 143) and by standard medicine (ascorbic acid) from 49.47% to 94.73% (IC50 103) using the ABTS technique in the evaluation of an antioxidant activity. Conclusion: Due to the presence of physiologically active phytocomponents, aerial sections of the Lagenaria siceraria (MEALS) were shown to be potent anthelmintic and antioxidant agents.
Keywords: Lagenaria siceraria, GC-MS study, Extraction, Antioxidant, Anthelmintic.