International Journal of Pharmaceutical Investigation, 2021, 11, 4, 414-419.
DOI: 10.5530/ijpi.2021.4.74
Published: December 2021
Type: Original Article
Authors:
Neelam Pawar
Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, INDIA.
Anoop Parmar
Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, INDIA.
Kavita Bahmani
Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, INDIA.
DN Mishra
Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, INDIA.
Renu Malik
Department of Pharmaceutical Sciences, Baba Masthnath University, Rohtak, Haryana, INDIA.
Neha Minocha
School of Medical and Allied Sciences, KR Manglam University, Gurugram, Haryana, INDIA.
Pawan Jalwal
Department of Pharmaceutical Sciences, Baba Masthnath University, Rohtak, Haryana, INDIA.
Rahul Pawar
Department of Pharmaceutical Sciences, Guru Jambheshwar University Science and Technology, Hisar, Haryana, INDIA.
ABSTRACT
Background: The optimization study was conducted in an attempt to develop a non-pressurized topical spray of Lidocaine without propellant. Methods: Central composite design was selected to determine the best conditions for the formulation of sprays with two independent factors were prepared (pH adjuster i.e sodium citrate and penetration enhancer i.e. propylene glycol). Concentration of propylene glycol (X1) of (5-25 ml) and sodium citrate (X2) of (0.5-2.0 ml) was the value range of the variables. F5 was ideally suited for use by spraying the container of a pump spray. Results: The drug content of F5 was 98.8% which indicates that the drug is distributed almost uniformly throughout the formulation and that there was no loss of drug in the formulation. Evaporation time and total number of delivery of F5 batch was about 2 min and 487. Drug content per actuation, diffusion study of F5 and marketed formulation were 97.64, 98.88 (at 6hr) and 68.64 (at 6 hr) respectively. The best fitted model for the drug content and evaporation time was quadric fit provided the value of r2 (0.9070 and 0.974) respectively. Conclusion: The research work concludes about the successful preparation of non-pressurized Lidocaine spray with local anesthetic action.
Keywords: Non-pressurized Topical Spray, Lidocaine, Meter Dose, Actuator, High-Density Polyethylene Plastic Bottles .