International Journal of Pharmaceutical Investigation, 2020, 10, 3, 279-285.
DOI: 10.5530/ijpi.2020.3.51
Published: October 2020
Type: Original Article
Authors:
Subramanaian Rajarajan
Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA
B Prakash Rao
Department of Pharmaceutical Technology, Karnataka College of Pharmacy, Bangalore, Karnataka, INDIA
S Selvamuthukumar
Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA
ABSTRACT
Objectives: The present systematic research is to design, develop clarithromycin nasal mucoadhesive microspheres for the utilisation in respiratory tract infection as alternative route of drug delivery. Methods: Current study designed to formulate, evaluated by using chitosan, beta cyclodextrin with modified emulsion lyophilisation method. 24 factorial design was used in optimization technique. Characterisation of prepared microspheres will be subjected for particle size and size distribution, drug entrapment study, in vitro drug diffusion studies and ex vivo mucoadhesion, surface morphology, zeta potential, infra-red radiation, differential scanning calorimetry, X-ray diffraction and stability studies. Results: The optimised formulation of predicted values of chitosan 0.604, Beta cylclodextrin 0.7633, Propeller Mixing Speed 9369 and Lyocycle temperatue of -42.8°C, Particle Size 14.06 μm, Entrapment efficiency 73.32%, Mucoadhesion 81.03 % and Maximum drug release 80.56%. Other finding results were satisfactory in control of quality attributes. Conclusion: Developed microspheres can be potential highlight on utilisation of clarithromycin as nasal drug delivery with beneficial as alternative dosage form for respiratory tract infections.
Keywords: Clarithromycin, Mucoadhesive microspheres, 24 Factorial Design, Nasal delivery, Beta cyclodextrin.