International Journal of Pharmaceutical Investigation, 2017, 7, 4, 188-192.
DOI: 10.4103/jphi.JPHI_82_17
Published: April 2018
Type: Original Article
Authors:
P. L. Ravishankar
Department of Periodontics, SRM Kattankulathur Dental College, Kanchipuram, Tamil Nadu, India.
Y. Pradeep Kumar
Department of Periodontics, SRM Kattankulathur Dental College, Kanchipuram, Tamil Nadu, India.
E. N. Anila
Department of Periodontics, SRM Kattankulathur Dental College, Kanchipuram, Tamil Nadu, India.
Priyankar Chakraborty
Department of Periodontics, SRM Kattankulathur Dental College, Kanchipuram, Tamil Nadu, India.
Maharshi Malakar
Department of Periodontics, SRM Kattankulathur Dental College, Kanchipuram, Tamil Nadu, India.
R. Mahalakshmi
Department of Periodontics, SRM Kattankulathur Dental College, Kanchipuram, Tamil Nadu, India.
ABSTRACT
Objective: The objective of this study is to evaluate the comparative effect of curcumin and ornidazole in treating chronic periodontitis. Materials and Methods: Twenty individuals of both sexes aged between 27 and 53 years diagnosed with chronic periodontitis and having pocket depths >5 mm bilaterally were selected for this study, in a split‑mouth design. Examination of plaque index, probing pocket depth and clinical attachment level was measured for each patient. The patients received a complete prophylaxis including scaling and root planing after which, both test gels were injected into the two experimental sites chosen, that had probing depth (PD) >5 mm and were located in symmetric quadrants. Pocket PD, clinical attachment loss and plaque index were recorded at days 0 and 30. Results: At 1‑month evaluation, curcumin group showed a significant decrease in pocket PD, plaque index and clinical attachment loss when compared to the ornidazole group. Conclusion: The results show a more favorable outcome with curcumin than ornidazole gel, thus curcumin can be used as an adjunct to nonsurgical periodontal therapy.
Keywords: Curcumin, Local drug delivery, Ornidazole .