International Journal of Pharmaceutical Investigation, 2018, 8, 1, 7-13.
DOI: 10.4103/jphi.JPHI_3_18
Published: July 2018
Type: Original Article
Authors:
Arlene Stuart Villarroel
[1]Department of Pharmacology and [2]School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, West Indies.
Madan Mohan Gupta
[2]School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, and [3]Laboratory of Pharmaceutical Formulation Design and Development, School of Pharmacy Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
Lexley M. Pinto Pereira
Department of Pharmacology, Faculty of Medical Sciences, The University of the West Indies.
Andanappa K. Gadad
School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
ABSTRACT
Objective: Metformin is a first‑line agent for the treatment of Type 2 diabetes. The taste of metformin hydrochloride drug powder is bitter and its formulation are orally used. The objective of this study was to make a complex of metformin hydrochloride with Indion‑254 resin for the purpose of preparation of dispersible tablet. Materials and Methods: This study formulated metformin hydrochloride–Indion‑254 complexes with different proportion of resin with fixed amount of drug as well as mixed at varying speed which improved the flowability. Results: The resulted complex was investigated by the help of Fourier Transform- Infrared Spectroscopy, differential scanning calorimetry, and X‑ray diffraction which were used to confirm complexation and to differentiate its features from the individual ingredients and the physical mixtures of ingredients. Conclusion: The formulated metformin hydrochloride–Indion‑254 complex showed better drug loading as well as good release in mixed phosphate buffer in 200 ml.
Keywords: Complex, Drug dissolution, Indion‑254, Metformin hydrochloride, Taste masking.