International Journal of Pharmaceutical Investigation, 2018, 8, 2, 83-91.
DOI: 10.4103/jphi.JPHI_29_18
Published: April 2018
Type: Original Article
Authors:
Akhilesh Dubey
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, Karnataka, India.
Amitha Shetty
Department of Pharmaceutics, Shree Devi College of Pharmacy, Mangalore, Karnataka, India.
G. S. Ravi
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, Karnataka, India.
Manan Christian Kiritkumar
Department of Pharmaceutics, Shree Devi College of Pharmacy, Mangalore, Karnataka, India.
Prabhakara Prabhu
Department of Pharmaceutics, Shree Devi College of Pharmacy, Mangalore, Karnataka, India.
Srinivas Hebbar
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, Karnataka, India.
Sally A. El‑Zahaby
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt.
ABSTRACT
Objective: The present study was aimed at formulating and evaluating a novel solid self‑nano emulsifying drug delivery system (SNEDDS) to increase the solubility and bioavailability of hydrochlorothiazide (HCZ). Enhancing both solubility and bioavailability of drugs remain the cornerstone for achieving successful outcomes of delivery systems. Furthermore, employing nanotechnology‑based formulations such as SNEDDS offers important advantage; the most important is the protection of the drug from enzymatic or chemical degradation. Materials and Methods: Liquid SNEDDS (L‑SNEDDS) was prepared by adding a drug to oil, surfactant, and co‑surfactant and heated up to at 60°C under continuous stirring. Solid SNEDDS (S‑SNEDDS) was prepared by mixing L‑SNEDDS with microcrystalline cellulose in 1:1 proportion. Results: The scanning electron microscopy showed that S‑SNEDDS was spherical with an average particle size of 66.9 nm and 69.2 nm for both L‑SNEDDS and S‑SNEDDS, respectively. Ex vivo skin permeation study indicated that 100% drug was released from both the L‑SNEDDS and S‑SNEDDS formulation SF3 in 3 h. Analysis of variance test showed significant differences (Moderately significant P < 0.01) in the values when compared to a marketed product. Conclusion: The prepared S‑SNEDDS helped in improving the solubility of the poorly soluble HCZ, which is a step forward toward bioavailability enhancement and thus increased therapeutic efficacy of the drug.
Keywords: Ex vivo, Hydrochlorothiazide, Self‑nanoemulsifying system, Solubility, Surfactant.