International Journal of Pharmaceutical Investigation, 2020, 10, 3, 237-245.
DOI: 10.5530/ijpi.2020.3.44
Published: October 2020
Type: Review Article
Authors:
Kuralla Hari
Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram, Andhra Pradesh, INDIA.
Sunkara Sai Prathyusha
Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram, Andhra Pradesh, INDIA.
Gokavarapu Vasavi
Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram, Andhra Pradesh, INDIA.
ABSTRACT
Colon Targeted Oral Drug Delivery System has gained much importance in recent times in delivering drug substance for the local action against colonic cancers, infections, Ulcerative Colitis (UC) and Crohn’s disease and for systemic action of protein peptides and non-peptide drugs include Cardiovascular and Antiasthamatics etc. This article gives an overview about the anatomy, physiology of colon and factors that are having influence on the formulation. Various approaches for colon targeting are specified and micro sponges are at forefront having unique, versatile and novel approach. Micro sponges are highly cross linked porous polymeric microspheres with many interconnected voids loaded with API that are released in a controlled manner. Micro sponges are designed to deliver efficiently at minimum dose with reduced side effects, enhancing the stability and solubility of active pharmaceutical ingredients. Further, the novel techniques in preparation, compiling the present research information with novel applications of drug delivery with micro sponges are highlighted.
Keywords: Crohn’s disease, Nanosponges, Quasi emulsion, Ulcerative Colitis, Colon, Targeting, Delivery systems.