International Journal of Pharmaceutical Investigation, 2022, 12, 2, 191-198.
DOI: 10.5530/ijpi.2022.2.34
Published: June 2022
Type: Original Article
Authors:
Sandip Ashok Murtale
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, INDIA.
Prakash Goudanavar
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, INDIA
Ankit Acharya
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, INDIA.
Jayatheertha Lokapur
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, INDIA.
Abstract
Background: In the medical and pharmaceutical fields, man has made successful use of natural origin things for millennia. Natural medications and excipients have piqued the interest of the entire globe today. Obtained from plant polymers have flashed a lot of attention in current decades because of their various pharmacological applications, such as gelling agents in gels as well as in, cosmo products, tablets, oral fluids, suspensions, and bases in a suppository. Objectives: Polymers are biocompatible, inexpensive, readily existing, and they are chosen over semisynthetic and artificial excipients. However, they have some drawbacks, including microbial contamination, lot to lot variation, reduced viscosity throughout storage, inappropriate mechanical properties, low strew and uninhibited rate of hydration. Materials and Methods: The thiolesterification technique, which uses thioglycolic acid (TGA) in the presence of a catalytic quantity of hydrochloric acid, was used to modify xanthan gum chemically. Microwave irradiated thiolated xanthan gum was also made by irradiating thiolated xanthan gum with a 750W frequency after it had been microwave irradiated. Modified and crude xanthan gum was used to make the sustained release tablet of Lornoxicam. Pre-compression and post-compression tests were performed on compressed tablets. Results: FT-IR, DSC, and X-ray diffraction investigations all show that grafting was successful. Additional peaks were identified in thiolated Xanthan gum and microwave irradiated gum, which were not present in pure Xanthan gum, according to FT-IR research. The presence of the SH stretch of the thiol group may be seen in the bands closer to 2568.00 cm-1 and 2584.70 cm- 1. Modified xanthan gum had a high swelling index. When compared to tablets made from crude xanthan gum, an in-vitro release study utilizing a pH 6.8 phosphate buffer indicated a sustain release of Lornoxicam from modified xanthan gum. Conclusion: Chemically modified xanthan gum sustains the drug over a prolonged period and could be a promising carrier in oral delivery to enhance anti-nociceptive and anti-inflammatory efficiency.
Keywords: Xanthan gum, Thiolated Xanthan gum, Micro-wave irradiated, Lornoxicam, Sustain drug release