International Journal of Pharmaceutical Investigation, 2022, 12, 3, 386-390.
DOI: 10.5530/ijpi.2022.3.65
Published: July 2022
Type: Original Article
Authors:
Jayatheertha S Lokapur
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
Prakash S Goudanavar
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
Arpitha J Lokapur
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
Ankit Acharya
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
Sandip A Murtale
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
ABSTRACT
Introduction: The objective of this task is to succeed with the trial of an ocularly efficient Timolol maleate formulation produced from prolonged proniosomal gel niosomes to get significant therapy for glaucoma. Methods: Cholesterol, Lecithin, Span 60, Brij 72, and Tween 80 in various concentrations were used to create Timolol maleate loaded proniosomal gel derived niosomes utilizing the phase coacervation method. Found on these outcomes of entrapment efficiency and in-vitro release, an optimised batch of proniosomal gel-produced niosomes was chosen. By spreading proniosomes in an in-situ gelling method, timolol maleate proniosomal gel-derived niosomes were created. Fourier transforms infrared spectroscopy (FTIR) experiments confirmed each interaction study. Wetting agent with additive effects on entrapment efficiency along with in-vitro drug release manner based on proniosomal gel-produced niosomes was investigated. Cholesterol, Lecithin, Span 60, Brij 72, and Tween 80 in various quantities were used in a coacervation technique, by dispersing proniosomes in an in-situ gelling method, a timolol maleate proniosomal gel was created. Results: The FTIR analyses revealed no signs of interaction between the medicine and the excipients, indicating that they are compatible. At the end of 12 hr, formulations T2 and T10 had 99.98 percent and 99.90 percent drug release, respectively. Conclusion: Starting with these findings secured, it can be closed this one proniosomal gel derived niosomes might be a satisfactory alternative to conventional eye drops as they exhibited elevated penetrability with sustained-release actions.
Keywords: Timolol maleate, Proniosomal gel, Phase co-acervation technique, Ocular delivery, Niosomes.