International Journal of Pharmaceutical Investigation, 2022, 12, 1, 39-45.
DOI: 10.5530/ijpi.2022.1.7
Published: March-2022
Type: Original Article
Authors:
Ankita Awasthi
School of Pharmacy and Research, People’s University, Bhopal, Madhya Pradesh, INDIA.
Bhaskar Kumar Gupta
School of Pharmacy and Research, People’s University, Bhopal, Madhya Pradesh, INDIA.
Papiya Bigoniya
DSKM College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, INDIA.
Abstract
Background: The present study was investigated about the anti-obesity effect of dill seed cake on rats fed with high fructose diet. Materials and Methods: 45 days experimental study of high fructose diet feeding induced obesity, dyslipidaemia, hormonal imbalance, insulin insensitivity and increased atherogenic index. The control rat continued to receive either a control diet or high fructose diet, and the treatment groups were fed high fructose diet with 6 % of Dill Seed Cake and Dill seed Cake alone (8 %) and high fructose diet with orlistat (12mg/kg I.P.) for a period of 6 week. Results: In result treatment of Dill Seed Cake along with feed material decreased the weight gain, normalized the dyslipidemia, hyperlipidaemia and hormonal imbalance, and reduced the serum cholesterol level. Rats fed with high fructose diet supplemented with 8gm/kg of Dill seed Cake significantly reduced the metabolic disorder, hormonal imbalance and hypothyroidism. Conclusion: Intake of Dill Seed Cake supplementation can be adopted as a therapeutic strategy for the prevention of high fructose diet induced obesity complications in rat.
Keywords: High fructose diet, Dill Seed Cake, Obesity, Dyslipidemia, Hormonal imbalance.