Nanostructured Lipid Carrier (NLC) and Solid Lipid Nanoparticles (SLN) Based Hydrogel for Delivery of Etodolac: A Comparative Investigation on Dermal Pharmacokinetic on Rat Skin

Objectives: The present work focus on to create Solid lipid nanoparticles (SLN) and nanostructured lipid Carrier (NLC) as transporters for effective delivery of Etodolac (ETD). Methods: Etodolac stacked SLN and NLC were set up by melting emulsification and hardening at low temperature method and they were portrayed for molecule size, zeta potential, encapsulation efficacy and in vitro discharge rate. Ex vivo dermatokinetic by tape stripping technique was explored in rat skin utilizing altered Franz diffusion cells. The praticle size and the surface electrical charge (ZP) have been assessed following after manufacturing of dispersion. Results: The particles stayed in their colloidal range after production by melt emulsification method. For all nano dispersion the encapsulation efficacy was higher than 75%. Differential Scanning calorimetry (DSC) were performed to portray the physicochemical properties of the SLN and NLC. Approximately Same amount of Etodolac release was facilitated through skin of rats from SLN-SA and NLC-SA. Conclusion: Research work could be concluded as successful development of Etodolac loaded SLN and NLC to increase the encapsulation efficiency of colloidal lipid carriers with benefit of higher performance in terms of long term stability and impart a sustaining Etodolac topical effect as well as faster relief from pain associated with arthritis.