• Home
  • Browse Issues
    • In Press
    • Current Issue
    • Special Issue
    • Past Issues
  • About
    • Editorial Board
    • Bibliographic Listings
    • Peer Review Process
    • Open Access Policy
    • Plagiarism Policy
    • Copyright Policy
    • Retraction Policy
    • Editorial Policy
    • Disclaimer
  • Author Guidelines
  • Submit Article
  • Contact

Subscribe to Updates

Get the latest creative news from FooBar about art, design and business.

Facebook Twitter Instagram
International Journal of Pharmaceutical Investigation
Facebook Twitter Instagram
Submit Article Author Guidelines
  • Home
  • Browse Issues
    1. In Press
    2. Current Issue
    3. Special Issue
    4. Past Issues
    5. View All

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023
  • About
    • Editorial Board
    • Bibliographic Listings
    • Peer Review Process
    • Open Access Policy
    • Plagiarism Policy
    • Copyright Policy
    • Retraction Policy
    • Editorial Policy
    • Disclaimer
  • Author Guidelines
  • Submit Article
  • Contact
International Journal of Pharmaceutical Investigation
Home»JPHI»Vol 11 Issue 1»Nanoparticles Containing Gel Formulation for the Treatment of Psoriasis
Vol 11 Issue 1

Nanoparticles Containing Gel Formulation for the Treatment of Psoriasis

April 1, 2021Updated:June 3, 20232 Mins Read
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

International Journal of Pharmaceutical Investigation, 2021, 11, 1, 76-81.
DOI: 10.5530/ijpi.2021.1.14
Published: April 2021
Type: Original Article

Authors: 

Ramila Prajapati
Department of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, INDIA

Jayvadan Patel
Department of Pharmaceutics, Nootan Pharmacy College, Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, INDIA

Anita Patel
Department of Pharmaceutics, Nootan Pharmacy College, Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, INDIA

ABSTRACT

Background: Psoriasis is a widespread chronic disease affecting 1-3% of total population and in most cases, treated by topical application of corticosteroids. Though, the topical route is very demanding because of the physicochemical nature of diseased stratum corneum and so no, single treatment works for every patient. The oral route is evidence for harsh side effects because of systemic immunosuppression which can be avoided by topical route. Objectives: The objective of the present study is to design, develop, and evaluate nanoparticulate gel containing Cyclosporine A for the treatment of psoriasis. Methods: Cyclosporine loaded nanoparticles were formulated by the modified nanoprecipitation technique and characterized for particle size, encapsulation efficiency, morphological analysis, drugpolymer compatibility study, powder x-ray diffraction analysis. Optimized formulation of Cyclosporine nanoparticles further converted into the gel using Carbopol 934. Results: Cyclosporine loaded nanoparticles showed a spherical shape with smooth surface. In vitro antiproliferative activity proved that cell viability was not affected with blank nanoparticles, as there was no effect of concentration and types of surfactant on cell viability causing no cell death. The gel formulation hydrates the skin which helps in the higher permeation of Cyclosporine loaded nanoparticulate gel. Conclusion: In vitro anti-psoriatic study suggested that the developed Cyclosporine nanoparticulate gel formulation exhibits improved dermal delivery of Cyclosporine and also nanoparticles had a superior effect on cell growth as compared to the free Cyclosporine. Dermal pharmacokinetic study established that the amount of Cyclosporine reaching the viable layer is slightly high for nanoparticulate gel as compared to free Cyclosporine. Thus, Cyclosporine loaded nanoparticulate gel formulation might be the potential delivery system for the treatment of psoriasis.

Keywords: Cyclosporine A, Dermal pharmacokinetic study, In vitro antipsoriatic study, Nanoprecipitation technique, Topical gel.

Original Article
Previous ArticleAdvanced Development of Carboxylic Acid Functionalized Multiwall Carbon Nanotubes as Safe Inhalation Drug Carrier
Next Article Development and Characterization of Fast Dissolving Buccal Strip of Frovatriptan Succinate Monoydrate for Buccal Delivery

Related Posts

Impact of Mobile Radiations on Gliclazide Tablet Formulation

July 21, 2023

Formulation and in vitro Evaluation of pH Dependent Colon Targeted Controlled Release Tablet of Mesalamine Containing Cyamopsis tetragonoloba Gum and Sodium Alginate

July 21, 2023

Formulation, Development and Characterization of Liposome-based Gel of Eberconazole Nitrate for Topical Delivery

July 21, 2023
Download PDF
Cite this Article
Citation Output

Read in Readcube
  • Download PDF
  • ReadCube
Citations & Metrics
Article Metrics
  • Dimensions Metrics
  • Page Views
  • Related
Total Views 0
Last Month Views 0
Click for PLUM.MX Metrics Search this article in Google Scholar Related Articles in Google Scholar Search related in PUBMED


About
About

publishing peer-reviewed scholarly reviews, themed issues and research articles within the entire scope of the Pharmaceutical field. The journal particularly aims to foster the dissemination of scientific information by publishing manuscripts related to Pharmacy and Related Fields.

We're accepting new submissions right now.

Facebook Twitter RSS
Editor Picks

Overview on Evolving Variants of Novel Coronavirus and Control Measures in India

July 5, 2023

An Overview of the Various Appropriate Types of Cell Lines for the Production of Monoclonal Antibodies

July 5, 2023

Ashwagandha: A Flagship Herb of Ayurveda from Past to Present Nano Era

July 5, 2023

Dental Pulp Stem Cells: Biology and Promise for Regenerative Medicine

July 5, 2023
STAY CONNECTED

Contact Editor-In-Chief
Editor, International Journal of Pharm Investigation
#9, Vinnse Tower, Wheeler Road Extn.
St. Thomas Town, 560084, Bangalore, INDIA
Email: editor@jpionline.org

© 2023 Phcog.Net | Published by : EManuscript.
  • Home
  • Submit Article
  • Disclaimer
  • Contact

Type above and press Enter to search. Press Esc to cancel.