• Home
  • Browse Issues
    • In Press
    • Current Issue
    • Special Issue
    • Past Issues
  • About
    • Editorial Board
    • Bibliographic Listings
    • Peer Review Process
    • Open Access Policy
    • Plagiarism Policy
    • Copyright Policy
    • Retraction Policy
    • Editorial Policy
    • Disclaimer
  • Author Guidelines
  • Submit Article
  • Contact

Subscribe to Updates

Get the latest creative news from FooBar about art, design and business.

Facebook Twitter Instagram
International Journal of Pharmaceutical Investigation
Facebook Twitter Instagram
Submit Article Author Guidelines
  • Home
  • Browse Issues
    1. In Press
    2. Current Issue
    3. Special Issue
    4. Past Issues
    5. View All

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    September 22, 2023

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    September 20, 2023

    Type3c Diabetes Mellitus

    September 20, 2023

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    September 20, 2023
  • About
    • Editorial Board
    • Bibliographic Listings
    • Peer Review Process
    • Open Access Policy
    • Plagiarism Policy
    • Copyright Policy
    • Retraction Policy
    • Editorial Policy
    • Disclaimer
  • Author Guidelines
  • Submit Article
  • Contact
International Journal of Pharmaceutical Investigation
Home»JPHI»Vol 9 Issue 4»Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn. Leaves Extracts in Gastric Ulcer Models in Rats
Vol 9 Issue 4

Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn. Leaves Extracts in Gastric Ulcer Models in Rats

December 12, 2019Updated:June 3, 20232 Mins Read
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

International Journal of Pharmaceutical Investigation, 2019, 9, 4, 187-194. 
DOI: 10.5530/ijpi.2019.4.35
Published: December 2019
Type: Original Article

Authors: 

Felix Facundo Taboada
Instituto de Biología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán and Instituto Superior de Investigaciones Biológicas (INSIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Chacabuco 461, San Miguel de Tucumán, ARGENTINA.

Natalia Cecilia Habib
Instituto de Biología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán and Instituto Superior de Investigaciones Biológicas (INSIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Chacabuco 461, San Miguel de Tucumán, ARGENTINA.

Susana Beatriz Genta
Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, ARGENTINA.

ABSTRACT

Background: Peptic ulcer is a disease caused by imbalance between protective and aggressive factors in the gastric mucosa. Acacia aroma Gill. ex Hook. and Arn. (tusca) is widely used in Argentinian’s folk medicine for gastrointestinal disorders. The present study was designed to evaluate the protective effect of two A. aroma leaf extracts, 5% infusion and 10% hydroalcoholic extract in experimental models of acute gastric ulceration in rats. Methods: The gastroprotective action of the extracts was evaluated in absolute ethanol-induced gastric lesion models in adult Westar rats through macroscopic, histological and biochemical analyses of the stomach and gastric wall. We also determined the effects on the gastric juice parameters with a pylorus ligature model in rats. Evaluation of the acute toxicity of each extract was performed in adult normal Wistar rats. All results were statistically analyzed. Results: The lowest effective dose was 150 mg/Kg for each extract. Both of them showed a high protection of the mucosa against absolute ethanol. Pre-treatments with the extracts produced a significant increase in adherent mucus. These extracts showed a free radical scavenging capacity and they caused a significant reduction of the malondialdehyde, reduced glutathione levels, catalase and myeloperoxidase activities. The animals presented no signs of acute toxicity indicating a high safety margin for both extracts. Conclusion: This study shows for the first time the gastroprotective efficacy of 5% infusion and 10% hydroalcoholic extract of A. aroma leaves, highlighting their benefits as a prophylactic approach to maintain the integrity of the gastric mucosa.

Keywords: Acute toxicity, Antioxidant activity, Gastroprotection, Tusca, Preclinical studies. 

Original Article
Previous ArticleAntidiabetic Potential of Flavones on Streptozotocin-induced Diabetes Mellitus in Rat
Next Article Evaluation of Nootropic activity of Ethanolic and Aqueous Root Extracts of Adhatoda vasica nees in Rodents

Related Posts

Impact of Mobile Radiations on Gliclazide Tablet Formulation

July 21, 2023

Formulation and in vitro Evaluation of pH Dependent Colon Targeted Controlled Release Tablet of Mesalamine Containing Cyamopsis tetragonoloba Gum and Sodium Alginate

July 21, 2023

Formulation, Development and Characterization of Liposome-based Gel of Eberconazole Nitrate for Topical Delivery

July 21, 2023
Download PDF
Cite this Article
Citation Output

Read in Readcube
  • Download PDF
  • ReadCube
Citations & Metrics
Article Metrics
  • Dimensions Metrics
  • Page Views
  • Related
Total Views 0
Last Month Views 0
Click for PLUM.MX Metrics Search this article in Google Scholar Related Articles in Google Scholar Search related in PUBMED


About
About

publishing peer-reviewed scholarly reviews, themed issues and research articles within the entire scope of the Pharmaceutical field. The journal particularly aims to foster the dissemination of scientific information by publishing manuscripts related to Pharmacy and Related Fields.

We're accepting new submissions right now.

Facebook Twitter RSS
Editor Picks

Overview on Evolving Variants of Novel Coronavirus and Control Measures in India

July 5, 2023

An Overview of the Various Appropriate Types of Cell Lines for the Production of Monoclonal Antibodies

July 5, 2023

Ashwagandha: A Flagship Herb of Ayurveda from Past to Present Nano Era

July 5, 2023

Dental Pulp Stem Cells: Biology and Promise for Regenerative Medicine

July 5, 2023
STAY CONNECTED

Contact Editor-In-Chief
Editor, International Journal of Pharm Investigation
#9, Vinnse Tower, Wheeler Road Extn.
St. Thomas Town, 560084, Bangalore, INDIA
Email: editor@jpionline.org

© 2023 Phcog.Net | Published by : EManuscript.
  • Home
  • Submit Article
  • Disclaimer
  • Contact

Type above and press Enter to search. Press Esc to cancel.