International Journal of Pharmaceutical Investigation, 2019, 9, 4, 158-163.
DOI: 10.5530/ijpi.2019.4.30
Published: December 2019
Type: Original Article
Authors:
R Govindharaju
Postgraduate and Research Department of Chemistry, Thanthai Hans Roever College (Autonomous), (Affiliated to Bharathidasan University), Perambalur, Tamil Nadu, INDIA.
N Muruganantham
Postgraduate and Research Department of Chemistry, Thanthai Hans Roever College (Autonomous), (Affiliated to Bharathidasan University), Perambalur, Tamil Nadu, INDIA.
S Balasubramaniyan
Postgraduate and Research Department of Chemistry, Government Arts College (Affiliated to Bharathidasan University), Ariyalur, Tamil Nadu, INDIA.
L Palanivelan
Postgraduate and Research Department of Chemistry, Government Arts College (Affiliated to Bharathidasan University), Ariyalur, Tamil Nadu, INDIA.
B Jayalakshmi
Department of Chemistry, Syed Ammal Engineering College (Affiliated to Anna University), Ramanathapuram, Tamil Nadu, INDIA.
K Rajalakshmi
Postgraduate and Research Department of Chemistry, Srimad Andavan Arts and Science College (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, INDIA.
T Ramachandramoorthy
Postgraduate and Research Department of Chemistry, Bishop Heber College (Autonomous), (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, INDIA.
ABSTRACT
Objectives: 2-aminobenzonitrile is used as the starting materials for the synthesis of many biologically active compounds. The main objective of the study was to synthesize, characterization and biological evaluation of a binuclear bridged Cr(III) complex containing 2-aminobenzonitrile (N,Ndonor) and octanoate ion (OC) as ligands. Methods: This study formulated, the required mole ratio of 2-aminobenzonitrile in methanol and sodium octanoate in ethanol were added to the chromium chloride in methanol followed by microwave irradiation for few seconds after each addition by using microwave oven and the precipitate was filtered off, washed with 1:1 ethanol: water and characterized by various spectral studies and biological significance. Results: The resulted complex was investigated by the help of elemental analysis, molar conductance, magnetic moment, electronic spectra, FT-IR, cyclic voltammetry, thermal analysis and powder-XRD techniques. The spectral data’s indicates that the geometry of the complex is octahedral. The antimicrobial activities of ligands and their Cr(III) complex were studied by agar-well diffusion method. The free radical scavenging activity of the complex and the ligands has been determined by measuring their interaction with the stable free radical DPPH. DNA-binding properties have been studied by fluorescence-emission method. Conclusion: The formulated Cr(III) complex showed moderate and potential activity against the tested bacteria, enhanced activity against the fungi and larger antioxidant activity as compared to the free ligands. The DNA binding study result suggests that the complex strongly binds to DNA.
Keywords: 2-aminobenzonitrile, N,N-donor, Antimicrobial, DNA binding.