International Journal of Pharmaceutical Investigation, 2012, 2, 1, 2-11.
DOI: 10.4103/2230-973X.96920
Published: June 2012
Type: Review Article
Authors:
Gaurav Tiwari
Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur, Rajasthan, India.
Ruchi Tiwari
Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur, Rajasthan, India.
Birendra Sriwastawa
Jaipur National University, Jagatpura, Jaipur, Rajasthan, India.
L Bhati
Mankind Research Centre, Manesar, Gurgaon, India.
S Pandey
Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur, Rajasthan, India.
P Pandey
Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur, Rajasthan, India
ABSTRACT
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery particularly for peptide and protein therapeutics. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and pulmonary delivery. These include liposomes, proliposomes, microspheres, gels, prodrugs, cyclodextrins, among others. Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable period of time.
Keywords: Brain Targeting, Infectious Diseases, Liposomal, Lung Diseases, Micelles, Transdermal.