International Journal of Pharmaceutical Investigation, 2011, 1, 4, 222-226.
DOI: 10.4103/2230-973X.93009
Published: February 2012
Type: Original Article
Authors:
Santosh S Bhujbal
Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India
Sunita S Hadawale
Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India
Parag A Kulkarni
Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India
Jayant S Bidkar
Sharadchandra Pawar College of Pharmacy, Dumberwadi (Otur), Junner, Pune, India
Vidya A Thatte
Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India
Clarine A Providencia
Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India
Rupesh R Yeola
Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India
ABSTRACT
Background and Aim: Momordica charantia Linn. is traditionally used as a medicine for diabetes. The present investigation was aimed to formulate and evaluate transdermal patchesof Momordica charantia Linn. Materials and Methods: The transdermal films containing the herbal drug component fractionated fromethanolicextract of M. charantia fruits were prepared by using hydroxy propyl methyl cellulose as a polymer.The films were evaluated for folding endurance, thickness, weight variation, drug contents and in vitro diffusion studies and in vivo parameterslike acute and sub-acute antihyperglycemic activity in diabetic rats, biochemicalstudies, skin irritation in rats and stability studies. Result and Discussion:The weightof transdermal patches of M. charantia (2 cm2; 10 mg/patch) and was found to be 0.03 gm.Thickness of patches of M. charantia (2 cm2; 10 mg/patch) was found to be satisfactory. The percentage release of active constituents from transdermal patches of M.charantia (2 cm2; 10 mg/patch) was found to be 47.59% in 10% hydroalcoholic phosphate buffer pH 7.4 at the end of 6 h. The transdermal route exhibited negligible skin irritation and in vivo results revealed that the patches successfully decrease the blood glucose level. Conclusion: From the results, we concluded that the well-known herbal drug M. charantia Linn. have been found to be effective for diabetes through modern pharmaceutical formulation techniques.
Keywords: Diabetes mellitus, Diethyl ether fraction, M. charantia Linn, Transdermal patch.