International Journal of Pharmaceutical Investigation, 2011, 1, 3, 182-191.
DOI: 10.4103/2230-973X.85971
Published: October 2011
Type: Original Article
Authors:
R Indira Prasanna
Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India
P Anitha
Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India
C Madhusudhana Chetty
Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India
ABSTRACT
Background: A novel aspiration in treatment of migraine, to provide greater therapeutic effect, overcome the side effects by complex therapeutic regimen and to improve patient compliance upon administering bucco-adhesive tablet formulations of sumatriptan succinate which have not been tested literally. Materials and Methods: This study was designed to develop a bucco-adhesive tablet containing sumatriptan succinate using blends of different bio-adhesive polymeric combinations such as hydroxy propyl methyl cellulose K4M, sodium carboxy methyl cellulose, and Carbopol 934P with a backing layer of ethyl cellulose by a direct compression technique. Tablets were subjected to physico-chemical parameters, swelling index, surface pH, ex vivo bioadhesive force, in vitro drug release, ex vivo drug permeation, and stability in saliva. Results: Good results were obtained in all the evaluated parameters. The drug release of all formulation follows zero-order kinetics by a diffusion mechanism type. Stability studies in human saliva, ex vivo buccal permeation studies by using sheep and porcine buccal mucosa were carried out for the optimized formulation (S4 CP:HPMC 3:1). Conclusion: The developed buccal drug delivery system containing sumatriptan succinate might be the alternative routes available to bypass the first pass metabolism and might be a milestone in the therapy of migraine and among all formulations S4 shows good controlled release results correlated with ex vivo permeation studies
Keywords: Bucco-adhesive tablet, Carbopol 934P, Ethyl cellulose, Ex vivo permeation studies, HPMC K4M, Migraine, Sodium carboxy methyl cellulose, Sumatriptan succinate.