International Journal of Pharmaceutical Investigation, 2011, 1, 2, 93-98.
DOI: 10.4103/2230-973X.82407
Published: June 2011
Type: Original Article
Authors:
Anita Saxena
School of Physical Sciences, Nanomaterials and Nanocomposites Laboratory, Jawaharlal Nehru University, India.
Abu Tahir
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
Mandeep Kaloti
School of Physical Sciences, Nanomaterials and Nanocomposites Laboratory, Jawaharlal Nehru University, India.
Javed Ali
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
Himadri B Bohidar
School of Physical Sciences, Nanomaterials and Nanocomposites Laboratory, Jawaharlal Nehru University, India.
ABSTRACT
The study was designed for the development of salbutamol-modified release tablet using various polymer composition of agar, gelatin A and gelatin B. The purpose is to observe the role of polymer composition on the modified dissolution rate of salbutamol. Pre-formulation trials were initiated by comprising different ratios of polymer blend in the tablets. Formulations were optimized based on their invitro release performed in enzyme free simulated gastric fluid (0.1 N HCl, pH 1.2). Dissolution profiles of tablets were compared among the tablets made of agar, gelatin A, gelatin B and their blends agar-gelatin A, agar-gelatin B, gelatin A-gelatin B and agar-gelatin A-gelatin B in 1:1 ratio. Polymer compositions were fixed based on our desired sustaining activity of the tablet which showed a biphasic release profile with immediate release followed by sustained release. Polymer blends were more effective in controlling drug release. The better controlling behavior of polymer blends was explained by specific interaction between polymer components, their network structure and polymer–drug interaction.
Keywords: Biopolymer blends, Biphasic release, in-vitro release, Simulated gastric fluid, Specific interaction.