International Journal of Pharmaceutical Investigation, 2015, 5, 2, 81-86.
DOI: 10.4103/2230-973X.153382
Published: March 2015
Type: Original Article
Authors:
Y. Deepthi
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur, Andhra Pradesh, India.
T. E. Gopalakrishna Murthy
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur, Andhra Pradesh, India.
ABSTRACT
Most of the currently available drugs are having poor water solubility and suffer from low oral bioavailability. One of the most promising approaches to deliver such insoluble drugs is by dissolving it in lipids, liquids or semi-solids to formulate new products.[1] Candesartan meets the requirement of high potency but it is poorly absorbed when administered as tablets. Therefore the prodrug Candesartan cilexitil is developed.[2] Two piece hard gelatin liquid filling capsules are one of the most logical approaches when choosing the best dosage form to deliver these new liquid formulations.[1] Liquid filled formulations were prepared by employing different cosolvents and surfactants. The formulation containing SLS-2%, PVP- 17.5%, PEG-15%, and PG-53% exhibited desire solubility, rheological property and found to be stable in hard gelatin capsules.
Keywords: Candesartan cilexitil, Poly ethylene glycol, Sodium lauryl sulphate, Poly vinyl pyrrolidine, Liquid fill hard gelatin capsules .