International Journal of Pharmaceutical Investigation, 2014, 4, 4, 215-225.
DOI: 10.4103/2230-973X.143128
Published: October 2014
Type: Original Article
Authors:
Suresh G Killedar
Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.
Ashwini B Nale
Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.
Harinath N more
Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.
Sameer J Nadaf
Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.
Anuja A Pawar
Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.
Umarfarukh S Tamboli
Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.
ABSTRACT
Introduction: Present work, is an effort toward exploring the potential of Cassia fistula Linn. seed gum as an extended release polymer and laxative. While, C. fistula pulp polymer has evaluated as suspending agent. Materials and Methods: For extended release application, total five batches (F1-F5) were prepared by varying the ratio of drug:polymer as 1:1, 1:2, 1:3, 1:4, and 1:5, respectively. The granules were prepared by wet granulation method and further evaluated for micromeritic properties such as angle of repose (θ), Carr’s compressibility index (CCI), and Hausner’s ratio. Further compacts were evaluated by hardness, thickness, swelling index, in-vitro dissolution, and so on. Laxative activity was evaluated by administration of seed polymer (100 mg/kg) alone or in combination with bisacodyl (2.5 mg/kg) in 1% Tween 80. Zinc oxide suspension was prepared by varying the concentration of C. fistula pulp polymer and compared with suspension made by use of tragacanth, sodium carboxymethyl cellulose and bentonite. Results: Result showed that granules were free flowing, while the compact extended the drug release up to 10 h (72.84 ± 0.98; batch F5) and followed Higuchi matrix release kinetics. This extended release might be due to the formation of polyelectrolyte complex because of gluco-mannose in seed gum. Result of in-vivo laxative activity showed that seed polymer reduced faeces weight after 24 h compared to control (P < 0.01). Conclusions: Pulp polymer showed good sedimentation volume, but alone fails to stabilize the suspension for a longer period, so it could be useful in combination with other suspending agents and can be useful as novel excipient.
Keywords: Diclofenac sodium, Extended release, Laxative, Suspending agent, Swelling index .