International Journal of Pharmaceutical Investigation, 2014, 4, 3, 107-108 .
Published: August 2014
Jasjeet Kaur Narang
Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India.
Administration of lipophilic drugs by oral route is a challenging task due to multiple factors which include poor solubilization of a drug in the gastrointestinal tract, P-glycoprotein efflux, significant first pass elimination attributed to predisposition through cytochrome P450 enzymes, all of which result in poor vivo bioavailability. Over the recent years, research has been directed toward the design of lipid-based carrier systems for delivery of hydrophobic drugs. These formulations comprise of a suitable combination of natural lipids with surfactants, cosurfactants and cosolvents. Read more…..