International Journal of Pharmaceutical Investigation, 2014, 4, 1, 15-18.
DOI: 10.4103/2230-973X.127735
Published: February 2014
Type: Original Article
Authors:
Suneela Pyreddy
Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.
Pandurangan Dinesh Kumar
Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.
Palanirajan Vijayaraj Kumar
School of Pharmacy, University College Sadaya International University, JalanMenara Gading, Kuala Lumpur, Malaysia.
ABSTRACT
Aim: The preparation of novel PEGylated PAMAM (poly-amidoamine) dendrimers for delivery of anti-HIV drug Efavirenz is reported. Method and Materials: About 5.0 G PAMAM dendrimers are prepared by ethylene diamine core via Michael addition by divergent method. PEGylation is done by polyethylene glycol 600 using epichlorhydrin as linker. PEGylated 5.0 G PAMAM dendrimers loaded with Efavirenz (EFV) are evaluated for FTIR, DSC, SEM, drug release and stability studies. Results and Conclusion: From the results it is proved that this method is less time consuming, inexpensive, and reproducible. Drug-release studies indicate, PEGylated 5.0 G PAMAM-EFV dendrimers have shown prolonged drugrelease property.
Keywords: Dendrimers, Efavirenz, Epichlorhydrin, Michael addition .