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International Journal of Pharmaceutical Investigation
Home»JPHI»Vol 3 Issue 4»In vitro and In vivo Assessment of Piroxicam Incorporated Aloe vera Transgel
Vol 3 Issue 4

In vitro and In vivo Assessment of Piroxicam Incorporated Aloe vera Transgel

November 14, 2013Updated:May 30, 20232 Mins Read
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International Journal of Pharmaceutical Investigation, 2013, 3, 4, 212 – 216.
DOI: 10.4103/2230-973X.121303
Published: November 2013
Type: Original Article

Authors: 

Vinesha Velam
Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.

Prasanna Raju Yalavarthi
Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.

CR Sundaresan
Department of Medicine, Faculty of Medicine, University College Sedaya International University, Kuala Lumpur, Malaysia.

KR Vandana
Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.

Thushara Bindu Dudala
Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.

Haritha Kodavatikanti
Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.

Harini Chowdary Vadlamudi
Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.

ABSTRACT

Background: The aim of the study was to develop piroxicam-Aloe vera gel (PAG) formulation and make a pharmacodynamic evaluation of the formulation. Materials and Methods: The gel was prepared by using carbopol 934 as gelling agent and methyl paraben as a preservative in an Aloe vera gel base. The formulated gel was also evaluated for physicochemical parameters like pH, viscosity, drug content and in vitro diffusion assessment. Pharmacodynamic activity of the formulation was evaluated in Wistar albino rats. The formulated gel was compared with that of similar marketed gel (commercial piroxicam gel (CPG)) against the same parameters. Results: From in vitro studies, an effective drug release from PAG was observed to be 68.17% when compared with that of the CPG (62.71%) at 180 min indicating better drug release from the gel formulated in this study. Percentage inhibition of edema was greater for the preparation of PAG (29.57 mean percent inhibition after 60 min) compared to marketed gel which exhibited 18.3% after 60 min. Conclusion: It was concluded from the results that the Aloe vera gel acts as an effective gel base to prepare piroxicam gel with high drug loading capacity and improved anti-inflammatory effect. From the statistical analysis the formulation of PAG showed better release than the CPG at p < 0.05 level of significance.

Keywords: Aloe vera, Carbopol 934, Edema, Flux, In vitro diffusion, Pharmacodynamic activity, Piroxicam, % Inhibition .

Original Article
Previous ArticleDevelopment and Evaluation of 6-mercaptopurine and Metoclopramide Polypill Formulation for Oral Administration: In-vitro and Ex vivo Studies
Next Article Formulation and Evaluation of Sustained Release Enteric-coated Pellets of Budesonide for Intestinal Delivery

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