International Journal of Pharmaceutical Investigation, 2013, 3, 1, 54-59.
DOI: 10.4103/2230-973X.108964
Published: March 2013
Type: Original Article
Authors:
Abdul Wadood Khan
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Sabna Kotta
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Sudha Rana
Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Brig S K Muzumdar Marg, New Delhi, India.
Shahid Husain Ansari
Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Rakesh Kumar Sharma
Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Brig S K Muzumdar Marg, New Delhi, India.
Javed Ali
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
ABSTRACT
Background: Increased use of the radioactive materials in the field of research, medical, nuclear power plant and industry has increased the risk of accidental exposure. Intentional use of the radioisotopes by terrorist organizations could cause exposure/contamination of a number of the population. In view of the accidental contamination, there is a need to develop self-usable decontamination formulations that could be used immediately after contamination is suspected. Materials and Methods: Present work was planned to optimize and develop self-usable radiation decontamination cream formulation. Various pharmaceutical parameters were characterized. 99m Tc- sodium pertechnetate was used as radiocontaminant. Static counts were recorded before and after decontamination using single photon emission computed tomography. Results: Decontamination efficacy of the cream was found to be 42% ± 3% at 0-0.5 h after the exposure. Primary skin irritancy test was satisfactory as no erythema or edema was observed visually after 2 weeks of the formulation application. Conclusion: The decontamination studies proved the potential of EDTA to remove the radiological contaminants effectively.
Keywords: Cream, Decontamination, Decontamination factor, Efficiency, Radio-isotope.