Development and Characterization of Fast Dissolving Buccal Strip of Frovatriptan Succinate Monoydrate for Buccal Delivery

  • Pankaj Bhatt School of Pharmacy, Glocal University, Mirzapur Pole, Uttar Pradesh, INDIA
  • Suruchi Singh School of Pharmacy, Glocal University, Mirzapur Pole, Uttar Pradesh, INDIA
  • Satish Kumar Sharma School of Pharmacy, Glocal University, Mirzapur Pole, Uttar Pradesh, INDIA
  • Sani Rabiu School of Pharmacy, Glocal University, Mirzapur Pole, Uttar Pradesh, INDIA
Keywords: Migraine, Fast Dissolving Film, Solvent casting method, Stability studies, Frovatriptan succinate monoydrate

Abstract

Objectives: Aim of the present research work is to prepared fast mouth dissolving film of frovatriptan succinate monoydrate. Methods: Fast dissolving buccal film is prepared by Solvent casting method, hydroxypropyl methylcellulose E3 and E15 are helpful in the film-forming polymer, plasticizer in polyethylene glycols disintegrant is croscarmellose sodium, the artificial sweetener in Sodium saccharin as, citric acid as saliva stimulant, fructose as diluents and natural sweetener, wild cherry as a flavour and Brilliant blue dye for elegance was selected for fast dissolving film preparation. By prism, software result is obtained and then evaluated using analysis of variance (ANOVA). Results: The result suggested that the formulation containing 20% w/w Sodium saccharin, 10% w/w fructose and 5% citric acid was found to effectively obscure the bitter taste of drug with best overall acceptability. The same composition of Sodium saccharin, citric acid and fructose were used for further optimization using design of an experiment to continue obscuring the bitter taste of frovatriptan succinate monoydrate. Simple lattice mixture design which is helpful in drug formulation by using polymer plasticizer and disintegrant concentration for disintegration time-independent variable tensile strength and percentage elongation for the response. Conclusion: The effect of each variable, two and three-factor interactions were studied. The batches were numerically optimized to give a design space. fast mouth dissolving films are also found to behave better patient compliance in all the age groups.

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Scanning Electron Microscope (SEM) Image of fast dissolving buccal film at 400x magnification
Published
2021-03-31
How to Cite
1.
Bhatt P, Singh S, Kumar Sharma S, Rabiu S. Development and Characterization of Fast Dissolving Buccal Strip of Frovatriptan Succinate Monoydrate for Buccal Delivery. ijpi [Internet]. 31Mar.2021 [cited 15May2021];11(1):69-5. Available from: https://jpionline.org/index.php/ijpi/article/view/983