Comparison of Effectiveness of Calendula officinalis Extract Gel with Lycopene Gel for Treatment of Tobacco-induced Homogeneous Leukoplakia: A Randomized Clinical Trial

  • Manisha Singh Department of Oral Medicine and Radiology, KLE Vishwanath Katti Institute of Dental Sciences, Belagavi, Karnataka, India
  • Anjana Bagewadi Department of Oral Medicine and Radiology, KLE Vishwanath Katti Institute of Dental Sciences, Belagavi, Karnataka, India
Keywords: Calendula officinalis, Leukoplakia, Lycopene

Abstract

Aim: The aim of the study is to assess the efficacy of Calendula officinalis gel as cost-effective treatment modality in comparison to lycopene gel in the treatment of leukoplakia. Materials and Methods: The study comprised of sixty patients of clinically diagnosed and histopathologically confirmed cases of homogeneous leukoplakia which were divided into Group I and Group II with thirty patients each. Group I patients were dispensed C. officinalis extract gel whereas Group II patients were given lycopene gel. The therapy was instituted for 1 month to assess the change in the size of the lesion at the baseline and posttreatment. Results: The results revealed a statistically significant difference in both Group I and Group II when the pre- and post-treatment results were compared in the same group. The mean difference in the reduction in size before and after treatment for Group I was 2.0% ±1.0 cm while for the Group II, it was 1.57% ±0.87 cm. The intergroup comparison for the evaluation of reduction in the size of the lesion did not reveal statistically significant results. Conclusion: C. officinalis extract gel can be effectively used as an alternative to conventional treatment modality.

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Application of gel at the site of lesion
Published
2017-07-24
How to Cite
1.
Singh M, Bagewadi A. Comparison of Effectiveness of Calendula officinalis Extract Gel with Lycopene Gel for Treatment of Tobacco-induced Homogeneous Leukoplakia: A Randomized Clinical Trial. ijpi [Internet]. 24Jul.2017 [cited 12Aug.2022];7(2):88-3. Available from: https://jpionline.org/index.php/ijpi/article/view/186