Protective Effect of Arjunakwatha and Arjunasheeta in Paracetamol-induced Kidney Injury in Rat Model

  • Supriya Bhowmick Department of Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, INDIA.
  • Deblina Giri Department of Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, INDIA.
  • Meghamala Mandal Department of Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, INDIA.
  • Shrabanti Pyne Department of Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, INDIA.
  • Pinku Pal Department of Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, INDIA.
  • Sanjay Das Department of Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, INDIA.
  • Dilip Kumar Nandi Department of Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, INDIA.
  • Koushik Das Department of Nutrition, Belda College, Belda, Paschim Medinipur, West Bengal, INDIA. https://orcid.org/0000-0002-6349-8251
Keywords: Arjunakwaatha, Arjunasheeta, Kidney injury, KIM-1, CKD.

Abstract

Background: Chronic kidney disease is now a global burden with an increased grade of morbidity and mortality due to the unavailability of particular medicines except for high-cost treatments like dialysis or kidney transplantation. Tribal people use their own indigenous preparation of medicinal plants for the prevention and treatment of kidney ailments. The present study was aimed at preparing Arjunakwaatha and Arjunasheeta, an indigenous preparation of the bark of Terminalia arjuna (TA) and its supplementation in the kidney injury rat model. Materials and Methods: In this study, rats were induced to kidney injury (KI) by intraperitoneal injection of paracetamol 15 mg/kg b.w. for 14 days and supplementation of Arjunakwaatha and Arjunasheeta with various doses continued the experimentation for 28 days. Results: Results showed that urea, creatinine, C-reactive protein (CRP), glutamine oxalic transaminase (GOT), glutamate pyruvate transaminase (GPT) in plasma, and malondialdehyde (MDA) in kidney tissue, urinary protein, and KIM-1 were significantly (p<0.05) increased in kidney injury rats when compared to normal control rats. Supplementation of Arjunakwaatha and Arjunasheeta with kidney injury rats significantly (p<0.05) decreased urea, creatinine, CRP, GOT, GPT, MDA, SOD, CAT, and GSH levels as compared to kidney injury rats. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed new low molecular weight urinary protein bands in kidney injury rats. The protective effects of Arjunakwaatha and Arjunasheeta present no band at this molecular level in normal rats. Conclusion: It has been concluded that Arjunakwaatha is the best indigenous preparation for kidney protection.

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Effects of different doses of Arjunakwaatha and Arjunasheeta on SOD activity of kidney tissue on Paracetamol-induced kidney injury in male rats
Published
2022-12-16
How to Cite
1.
Bhowmick S, Giri D, Mandal M, Pyne S, Pal P, Das S, Nandi DK, Das K. Protective Effect of Arjunakwatha and Arjunasheeta in Paracetamol-induced Kidney Injury in Rat Model. ijpi [Internet]. 16Dec.2022 [cited 27Jan.2023];13(1):53-1. Available from: https://jpionline.org/index.php/ijpi/article/view/1728