Novel Approach for the Cyclic Voltammetric Determination of an Antidepressant Drug (Dosulepin) in Pharmaceutical Formulations

  • Ram Lal Saini Department of Chemistry, Jai Narain Vyas University, Jodhpur, Rajasthan, INDIA.
  • Seema Parveen Department of Chemistry, Jai Narain Vyas University, Jodhpur, Rajasthan, INDIA
  • Rajni Bais Department of Chemistry, Jai Narain Vyas University, Jodhpur, Rajasthan, INDIA
Keywords: DPV, SWV, GCE and Drug formulations

Abstract

Background: This research was focused on the development of a quick, simple, precise, and cost-effective voltammetric method for quantifying dosulepin. Materials and Methods: The antidepressant drug (dosulepin) was assessed in pharmaceutical formulations using square wave voltammetric (SWV) and Differential pulse voltammetric (DPV) techniques at a glassy carbon potentiometric working electrodes (GCE). Results: Dosulepin demonstrated a single clear and sharp cathodic peak in the applied potential -0.7 to -0.75 V versus Ag/AgCl/KCl reference electrode. Results from cyclic voltammetry, DPV, and SWV revealed one reduction wave with a peak potential of -0.7 V at pH 7. The proposed method’s excellent sensitivity was demonstrated by the obtained LOD of 7.686 x10- 8 mol L-1and a LOQ of 2.589x10-7mol L-1bulk were by applying Differential Pulse Voltammmetry method. On other hand a LOD of 1.735x10-7mol L-1and a LOQ of 5.785x10-7mol L-1bulk dosulepin were achieved by applying the Square Wave Voltammetry method. Conclusion: The suggested methods might be recommended for usage in quantitative detection, product testing, and research laboratories.

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Cyclic voltammograms of 1×10-5 mol L-1 Dosulepin in BR buffer pH 7 at different scan rates: (a) 5 mVs-1 (b) 10 mVs-1 (c) 20 mVs-1 (d) 50 mVs-1
Published
2022-10-06
How to Cite
1.
Saini RL, Parveen S, Bais R. Novel Approach for the Cyclic Voltammetric Determination of an Antidepressant Drug (Dosulepin) in Pharmaceutical Formulations. ijpi [Internet]. 6Oct.2022 [cited 6Dec.2022];12(4):455-61. Available from: https://jpionline.org/index.php/ijpi/article/view/1513