Formulation and Evaluation of Timolol Maleate Proniosomal Gel for Ocular Drug Delivery

  • Jayatheertha S Lokapur Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
  • Prakash S Goudanavar Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
  • Arpitha J Lokapur Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
  • Ankit Acharya Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
  • Sandip A Murtale Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Nagamangala, Mandya, Karnataka, INDIA.
Keywords: Timolol maleate, Proniosomal gel, Phase co-acervation technique, Ocular delivery, Niosomes.

Abstract

Introduction: The objective of this task is to succeed with the trial of an ocularly efficient Timolol maleate formulation produced from prolonged proniosomal gel niosomes to get significant therapy for glaucoma. Methods: Cholesterol, Lecithin, Span 60, Brij 72, and Tween 80 in various concentrations were used to create Timolol maleate loaded proniosomal gel derived niosomes utilizing the phase coacervation method. Found on these outcomes of entrapment efficiency and in-vitro release, an optimised batch of proniosomal gel-produced niosomes was chosen. By spreading proniosomes in an in-situ gelling method, timolol maleate proniosomal gel-derived niosomes were created. Fourier transforms infrared spectroscopy (FTIR) experiments confirmed each interaction study. Wetting agent with additive effects on entrapment efficiency along with in-vitro drug release manner based on proniosomal gel-produced niosomes was investigated. Cholesterol, Lecithin, Span 60, Brij 72, and Tween 80 in various quantities were used in a coacervation technique, by dispersing proniosomes in an in-situ gelling method, a timolol maleate proniosomal gel was created. Results: The FTIR analyses revealed no signs of interaction between the medicine and the excipients, indicating that they are compatible. At the end of 12 hr, formulations T2 and T10 had 99.98 percent and 99.90 percent drug release, respectively. Conclusion: Starting with these findings secured, it can be closed this one proniosomal gel derived niosomes might be a satisfactory alternative to conventional eye drops as they exhibited elevated penetrability with sustained-release actions.

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Calibration curve of Timolol maleate in pH 7.4 phosphate buffer
Published
2022-07-26
How to Cite
1.
Lokapur JS, Goudanavar PS, Lokapur AJ, Acharya A, Murtale SA. Formulation and Evaluation of Timolol Maleate Proniosomal Gel for Ocular Drug Delivery. ijpi [Internet]. 26Jul.2022 [cited 12Aug.2022];12(3):386-90. Available from: https://jpionline.org/index.php/ijpi/article/view/1357