Ethyl Cellulose and Hydroxypropyl Methyl Cellulose Buoyant Microspheres of Metoprolol Succinate: Influence of pH Modifiers

  • Neha S Raut Department of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
  • Sachin Somvanshi Department of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
  • Amol B Jumde Department of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
  • Harsha M Khandelwal Department of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
  • Milind J Umekar Department of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
  • Nandkishor Ramdas Kotagale Department of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
Keywords: Ethyl cellulose, Floating microspheres, Hydroxypropyl methyl cellulose, Metoprolol succinate, Microenvironmental pH, PH modifiers

Abstract

Introduction: Incorporation of pH modifier has been the usual strategy employed to enhance the dissolution of weakly basic drug from floating microspheres. Microspheres prepared using a combination of both ethyl cellulose (EC) and hydroxypropyl methylcellulose (HPMC) which shows highest release were utilize to investigate the effect of fumaric acid (FA), citric acid (CA), ascorbic acid (AA) and tartaric acid (TA) (all 5-20% w/w) incorporation on metoprolol succinate (MS) release. Materials and Methods: EC, HPMC alone or in combination were used to prepare microspheres that floated in simulated gastric fluid and evaluated for a percent yield, drug entrapment, percent buoyancy and drug release. The higher drug release in combination (MS:HPMC:EC, 1:1:2) was selected for the evaluation of influence of pH modifiers on MS release. CA (5-20% w/w), AA (5-20% w/w), FA (5-20% w/w) and TA (5-20% w/w) were added and evaluated for drug release. Present investigation is directed to develop floating drug delivery system of MS by solvent evaporation technique. Results: The microspheres of MS:HPMC:EC (1:1:2) exhibited the highest entrapment (74.36 ± 2.18). The best percentage yield was obtained at MS:HPMC (1:1) (83.96 ± 1.50) and combination of MS:HPMC:EC (1:1:2) (79.23 ± 1.63). Conclusion: MS release from the prepared microspheres was influenced by changing MS-polymer, MS-polymer-polymer ratio and pH modifier. Although significant increment in MS release was observed with CA (20% w/w), TA (20% w/w) and AA (20% w/w), addition of 20% w/w FA demonstrated more pronounced and significant increase in drug entrapment as well as release from MS:HPMC:EC (1:1:2) buoyant microspheres.

Downloads

Download data is not yet available.
Scanning electron microphotographs of floating microspheres (a) microspheres with ethyl cellulose (EC), (b) microspheres with hydroxypropyl methyl cellulose (HPMC), (c) microspheres with HPMC:EC combination, (d) surface morphology of microspheres with HPMC: EC combination
Published
2013-10-03
How to Cite
1.
Raut NS, Somvanshi S, Jumde AB, Khandelwal HM, Umekar MJ, Kotagale NR. Ethyl Cellulose and Hydroxypropyl Methyl Cellulose Buoyant Microspheres of Metoprolol Succinate: Influence of pH Modifiers. ijpi [Internet]. 3Oct.2013 [cited 4Oct.2022];3(3):163-70. Available from: https://jpionline.org/index.php/ijpi/article/view/118