Design of Sustained Release Pellets of Ferrous Fumarate using Cow Ghee as Hot-melt Coating Agent

  • Dinesh M Sakarkar Depatment of Pharmaceutics, Sudhakarrao Naik Institute of Pharmacy, Pusad, Yawatmal, India
  • Avinash K Dorle Depatment of Pharmaceutics, Sudhakarrao Naik Institute of Pharmacy, Pusad, Yawatmal, India
  • Nilesh Manoharrao Mahajan Depatment of Pharmaceutics, IBSS College of Pharmacy, Malkapur, Buldana, India
  • Suresh Gendappa Sudke Depatment of Pharmaceutics, SGSPS Institute of Pharmacy, Kaulkhed, Akola, Maharashtra, India
Keywords: Agglomeration, Difference factor, Similarity factor, Theoretical release profile

Abstract

Introduction: The objective of the present study was to design ferrous fumarate (FF) sustained release (SR) pellets using of cow ghee (CG) as an important hot-melt coating (HMC) agent. Materials and Methods: The pellets were coated by HMC technique using CG and ethyl cellulose composition by conventional coating pan without the use of spray system. FF formulated as pellets and characterized with regard to the drug content and physico-chemical properties. Stability studies were carried out on the optimized formulation for a period of 6 months at 40 ± 2°C and 75 ± 5% relative humidity. Results: Pellets with good surface morphology and smooth texture confirmed by stereo micrographs. HMC is easy, efficient, rapid and simple method since virtually no agglomeration seen during coating. In-vitro release from pellets at a given level of coating and for present pellet size was dependent upon the physico-chemical property of the drug and mostly aqueous solubility of the drug. The selection of optimized FF formulation was confirmed by comparing percent cumulative drug release with theoretical release profile. Formulation F2 had difference factor (f1 ) and similarity factor (f2 ) values was found to be 5 and 66 respectively. F2 showed SR of drug for 8 h with cumulative per cent release of 98.03 ± 4.49%. Release kinetics indicates approximately zero order release pattern. HMC pellets were stable during the course of stability study. Conclusions: By means of HMC using CG and ethyl cellulose, SR pellets containing FF were successfully prepared.

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Stereo micrographs of ferrous fumarate pellets: (a) Uncoated pellets; (b) hot-melt coated pellets ×60
Published
2013-10-03
How to Cite
1.
Sakarkar DM, Dorle AK, Mahajan NM, Sudke SG. Design of Sustained Release Pellets of Ferrous Fumarate using Cow Ghee as Hot-melt Coating Agent. ijpi [Internet]. 3Oct.2013 [cited 4Oct.2022];3(3):151-6. Available from: https://jpionline.org/index.php/ijpi/article/view/114