Formulation Development and Characterization of Rapid Mouth Dissolving Film of Frovatriptan Succinate (RETRACTED)

  • Pankaj Bhatt Department of Pharmacology, School of Pharmacy, Glocal University, Mirzapur Pole, Uttar Pradesh, INDIA.
  • Suruchi Singh Department of Pharmacology, School of Pharmacy, Glocal University, Mirzapur Pole, Uttar Pradesh, INDIA.
  • Satish Kumar Sharma Department of Pharmacology, School of Pharmacy, Glocal University, Mirzapur Pole, Uttar Pradesh, INDIA.
  • Sani Rabiu Department of Pharmacology, School of Pharmacy, Glocal University, Mirzapur Pole, Uttar Pradesh, INDIA.
Keywords: Migraine, Rapid Dissolving Film, Solvent casting method, Stability studies, Frovatriptan Succinate

Abstract

NOTE: THE ARTICLE HAS BEEN RETRACTED BASED ON AUTHORS' REQUEST. 

Objectives: Aim of the present research work is to prepared rapid mouth dissolving film of frovatriptan Succinate. Methods: Rapid Dissolving Film is prepared by Solvent casting method, hydroxypropyl methylcellulose E3 and E15 are helpful in the film-forming polymer, plasticizer in propylene glycol disintegrant is croscarmellose sodium, the artificial sweetener in aspartame as, citric acid as saliva stimulant, xylitol as diluents and natural sweetener, wild cherry as a flavour and Brilliant blue dye for elegance was selected for Rapid Dissolving Film preparation. By prism, software result is obtained and then evaluated using analysis of variance (ANOVA). Results: The result suggested that the formulation containing 20% w/w aspartame, 10% w/w xylitol and 5% citric acid was found to effectively obscure the bitter taste of drug with best overall acceptability. The same composition of aspartame, citric acid and xylitol were used for further optimization using design of an experiment to continue obscuring the bitter taste of frovatriptan Succinate. Simple lattice mixture design which is helpful in drug formulation by using polymer plasticizer and disintegrant concentration for disintegration time-independent variable tensile strength and percentage elongation for the response. Conclusion: The effect of each variable, two and three-factor interactions were studied. The batches were numerically optimized to give a design space. Rapid mouth dissolving films are also found to behave better patient compliance in all the age groups.

NOTE: THE ARTICLE HAS BEEN RETRACTED BASED ON AUTHORS' REQUEST. 

Downloads

Download data is not yet available.
Figure 3: Scanning Electron Microscope (SEM) Image of Rapid Mouth Dissolving Film (RDF) at 500x magnification
Published
2020-12-10
How to Cite
1.
Bhatt P, Singh S, Sharma S, Rabiu S. Formulation Development and Characterization of Rapid Mouth Dissolving Film of Frovatriptan Succinate (RETRACTED). ijpi [Internet]. 10Dec.2020 [cited 26Jan.2021];10(4):479-85. Available from: http://jpionline.org/index.php/ijpi/article/view/802