Development of Time Controlled Chronomodulated Tablet with Swelling and Rupturable Layers: Optimization of Factors Influencing lag‑time and Drug Release

  • Mayur Desai Department of pharmaceutics, C. U. Shah College of Pharmacy & Research, Wadwan, Gujarat, India
  • Rishad R Jivani Department of pharmaceutics, C. U. Shah College of Pharmacy & Research, Wadwan, Gujarat, India
  • Laxman D Patel Department of pharmaceutics, C. U. Shah College of Pharmacy & Research, Wadwan, Gujarat, India
  • Noordin P Jivani Department of pharmaceutics, C. U. Shah College of Pharmacy & Research, Wadwan, Gujarat, India
  • Bhavin Sonagara Department of pharmaceutics, C. U. Shah College of Pharmacy & Research, Wadwan, Gujarat, India
Keywords: Asthma, Cronomodulated drug delivery, Montelukast sodium, Swelling layer

Abstract

Introduction: A tablet system consisting of cores coated with two layers of swelling and rupturable coatings was prepared and evaluated as time controlled chronomodulated tablet. Materials and Methods: Cores containing Montelukast sodium as model drug were prepared by direct compression and then coated sequentially with an inner swelling layer containing a HPMC E 5 and an outer rupturable layer of Eudragit RL/RS (1:1). A three‑factor, two‑level, full factorial design was used to investigate the influence of amount of HPMC E 5 and Eudragit RL/RS (1:1) on the responses, i.e., lag time to release and time required for 80% of drug to releases. The dissolution tests were studied using the USP paddle method at 50 rpm in 0.1 N HCL for 2 hr and than in phosphate buffer pH 6.8. Result: The lag time of the drug release decreased by increasing the inner swelling layer and increased by increasing the rupturing layer level. Conclusion: The results obtain from present study suggest that swelling come reputable coating approach gives desire drug release after lag time.

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Scanning electron microscopy of optimized batch (MD1)
Published
2013-02-06
How to Cite
1.
Desai M, Jivani RR, Patel LD, Jivani NP, Sonagara B. Development of Time Controlled Chronomodulated Tablet with Swelling and Rupturable Layers: Optimization of Factors Influencing lag‑time and Drug Release. ijpi [Internet]. 6Feb.2013 [cited 30Mar.2020];2(4):208-12. Available from: http://jpionline.org/index.php/ijpi/article/view/298