Development and Characterization of Novel Hydrogel Containing Antimicrobial Drug for Treatment of Burns

  • Vaishali Thakkar Department of Pharmaceutics, Anand Pharmacy College, Anand, Gujarat, India
  • Vaishali Korat Department of Pharmaceutics, Anand Pharmacy College, Anand, Gujarat, India
  • Lalji Baldaniya Department of Pharmaceutics, Anand Pharmacy College, Anand, Gujarat, India
  • Mukesh Gohel Department of Pharmaceutics, Anand Pharmacy College, Anand, Gujarat, India
  • Tejal Gandhi Department of Pharmaceutics, Anand Pharmacy College, Anand, Gujarat, India
  • Nirav Patel Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India
Keywords: Aloe vera, Cubogel, Histopathological study, In vivo burns healing, Novel nanaoparticulate system, Silver sulfadiazine

Abstract

Introduction: The aim of burn management and therapy is fast healing and epithelisation to prevent infection. The present study is concerned with the development and characterization of a novel nanaoparticulate system; cubosomes, loaded with silver sulfadiazine (SSD) and Aloe vera for topical treatment of infected burns. Methods: Cubosome dispersions were formulated by an emulsification technique using different concentrations of a lipid phase Glyceryl Monooleate (GMO) and Poloxamer 407. The optimum formulae were incorporated in an aloe vera gel containing carbopol 934, to form cubosomal hydrogels (cubogels). The cubogels were characterized by in vitro release of SSD, rheological properties, pH, bioadhesion, Transmission Electron Microscopy and in-vivo Wound Healing Study. Results: The results show that the different concentration of GMO had significant effect on particle size, % EE and in vitro drug release. From the in-vitro drug release pattern and similarity factor (f2), it was concluded that batch CG3 (15% GMO and 1% P407) exhibited complete and controlled drug release within 12 hour (i.e. 98.25%), better bio adhesion and superior burn healing as compared to the marketed product. Conclusion: The in vivo burns healing study in rats revealed that the prepared optimized cubogel containing SSD and aloe vera has superior burns healing rate than cubogel with only SSD and marketed preparation so, it may be successfully used in the treatment of deep second degree burn.

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Particle size analysis of batch CS5
Published
2016-08-01
How to Cite
1.
Thakkar V, Korat V, Baldaniya L, Gohel M, Gandhi T, Patel N. Development and Characterization of Novel Hydrogel Containing Antimicrobial Drug for Treatment of Burns. ijpi [Internet]. 1Aug.2016 [cited 4Aug.2020];6(3):158-6. Available from: http://jpionline.org/index.php/ijpi/article/view/272